Studies Highlight Results of PiXL Procedure for Non-Invasive Treatment of Low Myopia
Avedro said that non-surgical photorefractive intrastromal corneal collagen cross-linking, or PiXL, is a promising new treatment for vision improvement for low myopia, according to the results of two studies announced at the XXXIV Congress of the European Society of Cataract and Refractive Surgeons (ESCRS).
"PiXL is a groundbreaking, first-in-category development in the field of vision improvement," said Rajesh K. Rajpal, MD, Chief Medical Officer, Avedro. "We are thrilled with the progress in our clinical development and believe that PiXL represents a new non-invasive treatment paradigm for patients with low myopia. We are pleased to see these very promising early results."
According to a release, the first study, a prospective clinical trial conducted at Ruhr University Eye Hospital, Bochum, Germany, evaluated the safety and efficacy of epithelium-off PiXL. This 12 month study included 39 eyes (phakic and pseudophakic) in 2 groups (group 1: MRSE -1.0 D to -2.0 D, cyl. max. -0.75 D; group 2: MRSE -2.0 D to -3.0 D, cyl. max. -0.75 D).
Preliminary results at 12 months demonstrate significant improvement with mean uncorrected visual acutiy (UCVA) of 20/20 at 12 months, and no loss of best-corrected visual acuity (BCVA). Based on these early results, the data demonstrate that PiXL is a promising refractive procedure for low myopia, offering the potential for vision improvement without tissue ablation.
"The preliminary 12 month results build upon what we observed at the three and six month evaluations," said Dr. Matthias Elling, FEBO, Ruhr University Eye Hospital, Bochum, Germany. "Based on these outcomes, the long-term stability of PiXL treatment appears favorable. It is exciting to see the potential of this new procedure for the large numbers of patients currently wearing contact lenses who have chosen not to have traditional refractive surgery."
The second study, performed at Eagle Eye Centre in Singapore, designed to analyze the safety and efficacy of trans-epithelial PiXL in correcting low myopia, evaluated treatment results in 8 patients (14 myopic eyes, -1.62 0.6D, range -0.75 to -2.625D) who underwent the procedure and were followed for 9 months postoperatively. Efficacy findings included a mean myopia reduction of 0.75D at 9 months. Safety evaulations found no significant loss in endothelial cell count or BCVA, and no significant corneal haze post-procedure. A questionnaire administered at 6 months post-op also found high levels of patient satisfaction.
"In addition to the positive safety and efficacy findings, we were pleased to find a high satisfaction rate for the procedure with patients," said Dr. Lim Wee Kiak of Eagle Eye Centre in Singapore. "Current refractive procedures are invasive and weaken the cornea. PiXL is revolutionary in that it improves the refractive error by stiffening the cornea, while also being non-invasive. This technology has huge potential as an addition to our armamentarium for refractive corrections."
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THE DAILY VIEW
Papyrus Joins Forces with Designer Lela Rose
Papyrus is looking to bring the “elegance and style” of fashion to its greeting cards via a new designer collaboration series.
According to a release, the collaboration marks the first time a fashion design house and greeting card brand have joined forces to develop a custom greeting card collection.
Papyrus said it is partnering with American fashion designer Lela Rose to introduce the series. Rose will feature her "sophisticated yet modern style" in the debut card and gift collection, slated to launch during New York Fashion Week. The collection will be available in New York City Papyrus stores and select retailers in September, with availability expanding to all Papyrus locations and retailers in October.
"The fashion designer collaboration series is a celebration of the commitment Papyrus has to the arts, including a focus on the fashion industry, quality craftsmanship and trend-forward design," said Christy Kaprosy, President of Papyrus-Recycled Greetings. "We are delighted to have Lela Rose's elegant line lead the first Papyrus fashion designer collaboration program, and we are excited to bring more fashion designers to our loyal customers in the future."
The company noted the collection, which draws inspiration from some of Rose's recent runway designs, consists of 16 cards and five gift accessories, including gift bags, gift tissue, roll wrap and a gift tag set. It also will be available online at papyrusonline.com
"I'm thrilled to be the first designer to collaborate with Papyrus on their exclusive new fashion series," said Lela Rose. "This is a unique way to showcase our designs, silhouettes and prints, and extend the brand into a new category."
- Big Gift: Bill Gates, founder and co-chair of the Bill & Melinda Gates Foundation, has committed $50 million to fight the epidemic.
- Early Donation: In August, Paul G. Allen Family Foundation donated $2.8 million toward the outbreak in West Africa.
- Latest Pledge: Facebook founder Mark Zuckerberg and his wife Priscilla Chan this month pledged $25 million to the CDC.
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- Crowdfunding: Scripps Research Institute's Erica Ollman Saphire seeks to raise $100K for equipment to speed her work, partially funding by U.S. government.